Circulating MicroRNAs and Hyperglycemia

This five-year project addresses the role of a novel biomarker—plasma microRNA levels—in the development of hyperglycemia and insulin resistance, which lead to diabetes. The goal is to advance understanding of diabetes pathogenesis, improve early detection, and facilitate new interventions aimed at diabetes prevention.

Circulating miRNA Signatures of Beta-Cell Response to Metformin or Insulin in Youth with Dysglycemia

The goal of this two-year project is to identify circulating miRNAs that are related to insulin resistance and beta-cell failure despite pharmacotherapy in youth with prediabetes or early type 2 diabetes.