Highlights of recent faculty research.

Sugar-sweetened Beverage Consumption May Modify Associations between Genetic Variants in the CHREBP Locus and HDL-C and TG Concentrations

Haslam DE, Peloso GM, Guirette M, Imamura F, Bartz TM, Pitsillides AN, Wang CA, Li-Gao R, Westra JM, Pitkänen N, Young KL, Graff M, Wood AC, Braun KVE, Luan J, Kähönen M, Kiefte-de Jong JC, Ghanbari M, Tintle N, Lemaitre RN, Mook-Kanamori DO, North K, Helminen M, Mossavar-Rahmani Y, Snetselaar L, Martin LW, Viikari JS, Oddy WH, Pennell CE, Rosendaal FR, Ikram MA, Uitterlinden AG, Psaty BM, Mozaffarian D, Rotter JI, Taylor KD, Lehtimäki T, Raitakari OT, Livingston KA, Voortman T, Forouhi NG, Wareham NJ, de Mutsert R, Rich SS, Manson JE, Mora S, Ridker PM, Merino J, Meigs JB, Dashti HS, Chasman DI, Lichtenstein AH, Smith CE, Dupuis J, Herman MA, McKeown NM. Circ Genom Precis Med. 2021 Jul 16. doi: 10.1161/CIRCGEN.120.003288. Online ahead of print. PMID: 34270325.

Rare Coding Variants Associated with Electrocardiographic Intervals Identify Monogenic Arrhythmia Susceptibility Genes: A Multi-ancestry Analysis

Choi SH, Jurgens SJ, Haggerty CM, Hall AW, Halford JL, Morrill VN, Weng LC, Lagerman B, Mirshahi T, Pettinger M, Guo X, Lin HJ, Alonso A, Soliman EZ, Kornej J, Lin H, Moscati A, Nadkarni G, Brody JA, Wiggins KL, Cade BE, Lee J, Austin-Tse C, Blackwell T, Chaffin MD, Lee CJ, Rehm HL, Roselli C, Redline S, Mitchell BD, Sotoodehnia N, Psaty BM, Heckbert SR, Loos RJF, Vasan RS, Benjamin EJ, Correa A, Boerwinkle E, Arking DE, Rotter JI, Rich SS, Whitsel EA, Perez MV, Kooperberg C, Fornwalt BK, Lunetta KL, Ellinor PT, Lubitz SA. Circ Genom Precis Med. 2021 Jul 28. doi: 10.1161/CIRCGEN.120.003300. Online ahead of print. PMID: 34319147.

Identification of novel and rare variants associated with handgrip strength using whole genome sequence data from the NHLBI Trans-Omics in Precision Medicine (TOPMed) Program

Sarnowski C, Chen H, Biggs ML, Wassertheil-Smoller S, Bressler J, Irvin MR, Ryan KA, Karasik D, Arnett DK, Cupples LA, Fardo DW, Gogarten SM, Heavner BD, Jain D, Kang HM, Kooperberg C, Mainous AG, Mitchell BD, Morrison AC, O'Connell JR, Psaty BM, Rice K, Smith AV, Vasan RS, Windham BG, Kiel DP, Murabito JM, Lunetta KL; TOPMed Longevity and Healthy Aging Working Group; from the NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium. PLoS One. 2021 Jul 2;16(7):e0253611. doi: 10.1371/journal.pone.0253611. eCollection 2021. PMID: 34214102. 

BinomiRare: A robust test for association of a rare genetic variant with a binary outcome for mixed models and any case-control proportion

Sofer T, Lee J, Kurniansyah N, Jain D, Laurie CA, Gogarten SM, Conomos MP, Heavner B, Hu Y, Kooperberg C, Haessler J, Vasan RS, Cupples LA, Coombes BJ, Seyerle A, Gharib SA, Chen H, O'Connell JR, Zhang M, Gottlieb DJ, Psaty BM, Longstreth WT Jr, Rotter JI, Taylor KD, Rich SS, Guo X, Boerwinkle E, Morrison AC, Pankow JS, Johnson AD, Pankratz N; NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Reiner AP, Redline S, Smith NL, Rice KM, Schifano ED. HGG Adv. 2021 Jul 8;2(3):100040. doi: 10.1016/j.xhgg.2021.100040. Epub 2021 Jun 12. PMID: 34337551. 

Communication regarding adverse neonatal birth events: Experiences of parents and clinicians

Loren, Davia Liba, Anne Drapkin Lyerly, Lauren Lipira, Madelene Ottosen, Emily Namey, Thomas Benedetti, Benjamin S Dunlap, Eric J Thomas, Carolyn Prouty, and Thomas H Gallagher. Journal of Patient Safety and Risk Management. July 2021. doi:10.1177/25160435211017749.

Using social security number to identify sub-populations vulnerable to the health impacts from extreme heat in Florida, U.S.

Jung J, Uejio CK, Adeyeye TE, Kintziger KW, Duclos C, Reid K, Jordan M, Spector JT, Insaf TZ. Environ Res. 2021 Jul 28;202:111738. doi: 10.1016/j.envres.2021.111738. Online ahead of print. PMID: 34331925.

Proposed SGIM Position Related to Health Effects of Climate Change

William G. Weppner, Andrea Christopher, Matthew F. Hollon, Elizabeth Gillespie, Gaurab Basu, on behalf of the Environmental Health Interest Group and Health Policy Committee. 2021. SGIM Position Statements/Policy Papers. Society of General Internal Medicine. 

Identifying and Prioritizing Workplace Climate Predictors of Burnout Among VHA Primary Care Physicians

Sterling R, Rinne ST, Reddy A, Moldestad M, Kaboli P, Helfrich CD, Henrikson NB, Nelson KM, Kaminetzky C, Wong ES. J Gen Intern Med. 2021 Jul 29:1-8. doi: 10.1007/s11606-021-07006-x. Online ahead of print. PMID: 34327656. 

Reach, engagement and effectiveness of in-person and online lifestyle change programs to prevent diabetes

Golovaty I, Wadhwa S, Fisher L, Lobach I, Crowe B, Levi R, Seligman H. BMC Public Health. 2021 Jul 5;21(1):1314. doi: 10.1186/s12889-021-11378-4. PMID: 34225674. 

Multiethnic Genome-wide Association Study of Subclinical Atherosclerosis in Individuals with Type 2 Diabetes

Lu Y, Dimitrov L, Chen SH, Bielak LF, Bis JC, Feitosa MF, Lu L, Kavousi M, Raffield LM, Smith AV, Wang L, Weiss S, Yao J, Zhu J, Gudmundsson EF, Gudmundsdottir V, Bos D, Ghanbari M, Ikram MA, Hwang SJ, Taylor KD, Budoff MJ, Gíslason GK, O'Donnell CJ, An P, Franceschini N, Freedman BI, Fu YP, Guo X, Heiss G, Kardia SLR, Wilson JG, Langefeld CD, Schminke U, Uitterlinden AG, Lange LA, Peyser PA, Gudnason VG, Psaty BM, Rotter JI, Bowden DW, Ng MCY. Circ Genom Precis Med. 2021 Jul 9. doi: 10.1161/CIRCGEN.120.003258. Online ahead of print. PMID: 34241534.