Highlights of recent faculty research.

Overlap Between Medicare's Comprehensive Care for Joint Replacement Program and Accountable Care Organizations

Liao JM, Shan EZ, Zhao Y, Shah Y, Cousins DS, Navathe AS. J Arthroplasty. 2021 Jan;36(1):1-5. doi: 10.1016/j.arth.2020.07.039. Epub 2020 Jul 22. PMID: 32792203. 

Comparison of Diagnostic Accuracy for Lower-Extremity Amputation Codes During the ICD-9 and ICD-10 Eras in a High-Risk Population of Patients with Diabetes

Littman AJ, Timmons AK, Moore KP, Tseng CL, Landry G, Robbins JM, Korpak A, Boyko EJ. Diabetes Care. 2021 Jan 12:dc202452. doi: 10.2337/dc20-2452. Online ahead of print. PMID: 33436400.

Whole genome sequence analyses of eGFR in 23,732 people representing multiple ancestries in the NHLBI trans-omics for precision medicine (TOPMed) consortium

Lin BM, Grinde KE, Brody JA, Breeze CE, ... Abecasis G, Psaty BM, Arnett DK, Boerwinkle E, Cai J, Yii-Der Chen I, Correa A, Cupples LA, He J, Kardia SL, Kooperberg C, Mathias RA, Mitchell BD, Nickerson DA, Turner ST, Ramachandran VS, Rotter JI, Levy D, Kramer HJ, Köttgen A, Nhlbi Trans-Omics For Precision Medicine TOPMed Consortium, TOPMed Kidney Working Group, Rich SS, Lin DY, Browning SR, Franceschini N. EBioMedicine. 2021 Jan;63:103157. doi: 10.1016/j.ebiom.2020.103157. Epub 2021 Jan 6. PMID: 33418499.

What improves the likelihood of people receiving genetic test results communicating to their families about genetic risk?

Bowen DJ, Makhnoon S, Shirts BH, Fullerton SM, Larson E, Ralston JD, Leppig K, Crosslin DR, Veenstra D, Jarvik GP. Patient Educ Couns. 2021 Jan 7:S0738-3991(21)00001-X. doi: 10.1016/j.pec.2021.01.001. Online ahead of print. PMID: 33455827.

Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability

Lagou V, Mägi R, Hottenga JJ, … Siscovick DS, Watkins H, Lecoeur C, Vollenweider P, Franco-Cereceda A, Eriksson P, Jarvelin MR, Stefansson K, Hamsten A, Nicholson G, Karpe F, Dermitzakis ET, Lindgren CM, McCarthy MI, Froguel P, Kaakinen MA, Lyssenko V, Watanabe RM, Ingelsson E, Florez JC, Dupuis J, Barroso I, Morris AP, Prokopenko I; Meta-Analyses of Glucose and Insulin-related traits Consortium (MAGIC). Nat Commun. 2021 Jan 5;12(1):24. doi: 10.1038/s41467-020-19366-9. PMID: 33402679. 

Meta-analysis of sample-level dbGaP data reveals novel shared genetic link between body height and Crohn's disease

Di Narzo A, Frades I, Crane HM, Crane PK, Hulot JS, Kasarskis A, Hart A, Argmann C, Dubinsky M, Peter I, Hao K. Hum Genet. 2021 Jan 16. doi: 10.1007/s00439-020-02250-3. Online ahead of print. PMID: 33452914.

Genome-wide meta-analysis of muscle weakness identifies 15 susceptibility loci in older men and women

Jones G, Trajanoska K, Santanasto AJ, … de Groot LCPGM, Psaty BM, Odden MC, Fohner AE, Langenberg C, Wareham NJ, Bandinelli S, van Schoor NM, Huisman M, Tan Q, Zmuda J, Mellström D, Karlsson M, Bennett DA, Buchman AS, De Jager PL, Uitterlinden AG, Völker U, Kocher T, Teumer A, Rodriguéz-Mañas L, García FJ, Carnicero JA, Herd P, Bertram L, Ohlsson C, Murabito JM, Melzer D, Kuchel GA, Ferrucci L, Karasik D, Rivadeneira F, Kiel DP, Pilling LC. Nat Commun. 2021 Jan 28;12(1):654. doi: 10.1038/s41467-021-20918-w. PMID: 33510174.

Genome-Wide Association Study of Circulating Interleukin 6 Levels Identifies Novel Loci

Ahluwalia TS, Prins BP, Abdollahi M, Armstrong NJ, Aslibekyan S, Bain L, Jefferis B, Baumert J, Beekman M, Ben-Shlomo Y, Bis JC, Mitchell BD, … Boerwinkle E, Psaty BM, Snieder H, Alizadeh BZ. Hum Mol Genet. 2021 Jan 30:ddab023. doi: 10.1093/hmg/ddab023. Online ahead of print. PMID: 33517400.

Preliminary comparison of vibration measurement accuracy between a low cost, portable acceleration measurement unit and a gold-standard accelerometer system

Pierson B, Faestel P, Spector JT, Johnson P. Appl Ergon. 2021 Jan;90:103268. doi: 10.1016/j.apergo.2020.103268. Epub 2020 Sep 25. PMID: 32987260.

Fine Particulate Matter and Markers of Alzheimer's Disease Neuropathology at Autopsy in a Community-Based Cohort

Shaffer RM, Li G, Adar SD, Dirk Keene C, Latimer CS, Crane PK, Larson EB, Kaufman JD, Carone M, Sheppard L. J Alzheimers Dis. 2021 Jan 13. doi: 10.3233/JAD-201005. Online ahead of print. PMID: 33459717.