Highlights of recent faculty research.

Basket Cases: How Real-World Testing for Drugs Approved Based on Basket Trials Might Lead to False Diagnoses, Patient Risks, and Squandered Resources

Ramsey SD, Shankaran V, Sullivan SD. J Clin Oncol. 2019 Jun 24:JCO1802320. doi: 10.1200/JCO.18.02320. PMID: 31233352 

Pharmacogenomics of statin-related myopathy: Meta-analysis of rare variants from whole-exome sequencing

Floyd JS, Bloch KM, Brody JA, Maroteau C, Siddiqui MK, Gregory R, Carr DF, Molokhia M, Liu X, Bis JC, Ahmed A, Liu X, Hallberg P, Yue QY, Magnusson PKE, Brisson D, Wiggins KL, Morrison AC, Khoury E, McKeigue P, Stricker BH, Lapeyre-Mestre M, Heckbert SR, Gallagher AM, Chinoy H, Gibbs RA, Bondon-Guitton E, Tracy R, Boerwinkle E, Gaudet D, Conforti A, van Staa T, Sitlani CM, Rice KM, Maitland-van der Zee AH, Wadelius M, Morris AP, Pirmohamed M, Palmer CAN, Psaty BM, Alfirevic A, PREDICTION-ADR Consortium and EUDRAGENE. PLoS One. 2019 Jun 26;14(6):e0218115. doi: 10.1371/journal.pone.0218115. eCollection 2019. PMID: 31242253 

Adverse Events Experienced by Patients Hospitalized without Definite Medical Acuity: A Retrospective Cohort Study

Sekijima A, Sunga C, Bann M. J Hosp Med. 2019 Jun 19;14:E1-E4. doi: 10.12788/jhm.3235. PMID: 31251157 

Associations Between Depression, Traumatic Brain Injury, and Cognitively-Defined Late-Onset Alzheimer's Disease Subgroups.

Bauman J, Gibbons LE, Moore M, Mukherjee S, McCurry SM, McCormick W, Bowen JD, Trittschuh E, Glymour M, Mez J, Saykin AJ, Dams-O'Conner K, Bennett DA, Larson EB, Crane PK, Executive Prominent AD (EPAD) investigators. J Alzheimers Dis. 2019 Jun 24. doi: 10.3233/JAD-181212. PMID: 31256124

Safety and Pharmacokinetics of Single-Dose Novel Oral Androgen 11β-Methyl-19-Nortestosterone-17β-Dodecylcarbonate in Men

Wu S, Yuen F, Swerdloff RS, Pak Y, Thirumalai A, Liu PY, Amory JK, Bai F, Hull L, Blithe DL, Anawalt BD, Parman T, Kim K, Lee MS, Bremner WJ, Page ST, Wang C.  J Clin Endocrinol Metab. 2019 Mar 1;104(3):629-638. doi: 10.1210/jc.2018-01528. PMID: 30252057 

We want to know: patient comfort speaking up about breakdowns in care and patient experience

Fisher KA, Smith KM, Gallagher TH, Huang JC, Borton JC, Mazor KM. BMJ Qual Saf. 2019 Mar;28(3):190-197. doi: 10.1136/bmjqs-2018-008159. Epub 2018 Sep 29. PMID: 30269059 

A Curriculum for Diagnostic Reasoning: JGIM's Exercises in Clinical Reasoning

Subramanian A, Connor DM, Berger G, Lessing JN, Mehta N, Manesh R, Kohlwes J. J Gen Intern Med. 2019 Mar;34(3):344-345. doi: 10.1007/s11606-018-4689-y. PMID: 30334181

Brain Health and Dementia Prevention: A Mixed-method Analysis

Marcum ZA, Hohl SD, Gray SL, Barthold D, Crane PK, Larson EB. Am J Health Behav. 2019 Mar 1;43(2):300-310. doi: 10.5993/AJHB.43.2.7. PMID: 30808470

Capsule Commentary on Wakeman et al., Effect of Integrating Substance Use Disorder Treatment into Primary Care on Inpatient and Emergency Department Utilization

Klein JW. J Gen Intern Med. 2019 Mar 11. doi: 10.1007/s11606-019-04919-6. PMID: 30859508

Provider and patient perspectives on barriers to buprenorphine adherence and the acceptability of video directly observed therapy to enhance adherence

Godersky ME, Saxon AJ, Merrill JO, Samet JH, Simoni JM, Tsui JI. Addict Sci Clin Pract. 2019 Mar 13;14(1):11. doi: 10.1186/s13722-019-0139-3. PMID: 30867068