Highlights of recent faculty research.

Polygenic transcriptome risk scores for COPD and lung function improve cross-ethnic portability of prediction in the NHLBI TOPMed program

Hu X, Qiao D, Kim W, … Wilson JG, Psaty BM, Fornage M, … TOPMed Lung Working Group, Cho MH, Im HK, Manichaikul A. Am J Hum Genet. 2022 May 5;109(5):857-870. doi: 10.1016/j.ajhg.2022.03.007. Epub 2022 Apr 5. PMID: 35385699.

Long-Term Trends in Home Respiratory Medical Equipment among US Medicare Patients, 2013–2019

Duan KI, Wong ES, Liao JM, Sabbatini AK, Au DH. Am J Respir Crit Care Med. 2022 May 13. doi: 10.1164/rccm.202202-0238LE. Online ahead of print. PMID: 35549846.  

My Goals Are Not Their Goals: Barriers and Facilitators to Delivery of Patient-Centered Care for Patients with Multimorbidity

Schuttner L, Hockett Sherlock S, Simons CE, Johnson NL, Wirtz E, Ralston JD, Rosland AM, Nelson K, Sayre G. J Gen Intern Med. 2022 May 23:1-8. doi: 10.1007/s11606-022-07533-1. Online ahead of print. PMID: 35606644. 

Sex differences in the genetic architecture of cognitive resilience to Alzheimer's disease

Eissman JM, Dumitrescu L, Mahoney ER, Smith AN, Mukherjee S, Lee ML, Scollard P, Choi SE, Bush WS, … Hadad N, Sanders RE, Ruderfer DM, … Alzheimer’s Disease Neuroimaging Initiative (ADNI); Alzheimer’s Disease Genetics Consortium (ADGC); A4 Study Team, … Saykin AJ, Larson EB, Sperling RA, … Schneider JA, Crane PK, Jefferson AL, Hohman TJ. Brain. 2022 May 13:awac177. doi: 10.1093/brain/awac177. Online ahead of print. PMID: 35552371.

Gene-mapping study of extremes of cerebral small vessel disease reveals TRIM47 as a strong candidate

Mishra A, Duplaà C, Vojinovic D, … Luciano M, Bis JC, Adams HHH, … DeCarli CS, Psaty BM, Tzourio C, … Longstreth WT, Couffinhal T, Debette S. Brain. 2022 May 2:awab432. doi: 10.1093/brain/awab432. Online ahead of print. PMID: 35511193.

Association of Peripheral Lymphocyte Subsets with Cognitive Decline and Dementia: The Cardiovascular Health Study

Fohner AE, Sitlani CM, Buzkova P, Doyle MF, Liu X, Bis JC, Fitzpatrick A, … Tracy RP, Psaty BM, Delaney JA, Floyd JS. J Alzheimers Dis. 2022 May 6. doi: 10.3233/JAD-220091. Online ahead of print. PMID: 35527553. 

Association of cerebral microvascular dysfunction and white matter injury in Alzheimer's disease

Bagi Z, Kroenke CD, Fopiano KA, Tian Y, Filosa JA, Sherman LS, Larson EB, Keene CD, Degener O'Brien K, Adeniyi PA, Back SA. Geroscience. 2022 May 25. doi: 10.1007/s11357-022-00585-5. Online ahead of print. PMID: 35612774.

Isotretinoin and its metabolites alter mRNA of multiple enzyme and transporter genes in vitro but downregulation of OATP1B1 does not translate to the clinic

Yadav AS, Stevison F, Kosaka M, Wong S, Kenny JR, Amory JK, Isoherranen N. Drug Metab Dispos. 2022 May 11:DMD-AR-2022-000882. doi: 10.1124/dmd.122.000882. Online ahead of print. PMID: 35545255.

Association of Trimethylamine N-Oxide and Metabolites with Mortality in Older Adults

Fretts AM, Hazen SL, Jensen P, Budoff M, Sitlani CM, Wang M, de Oliveira Otto MC, DiDonato JA, Lee Y, Psaty BM, Siscovick DS, Sotoodehnia N, Tang WHW, Lai H, Lemaitre RN, Mozaffarian D. JAMA Netw Open. 2022 May 2;5(5):e2213242. doi: 10.1001/jamanetworkopen.2022.13242. PMID: 35594043.

Continuity and Health Outcomes in Resident Clinics: A Scoping Review of the Literature

Connolly M J, Weppner W G, Fortuna R J, Snyder E D. (May 20, 2022) Cureus 14(5): e25167. doi:10.7759/cureus.25167.