Michael Lenaeus, headshot
Assistant Professor
Medicine

Faculty Information

Biography
Education & Training: 
PhD
Northwestern University
Chicago, IL
2009
MD
Northwestern University, Feinberg School of Medicine
Chicago, IL
2010
Internship and Residency in Medicine
University of Washington
Seattle, WA
2010–2013
Honors: 
Graduated Summa Cum Laude from Gonzaga University
2003
Best Research Poster, MSTP Retreat
2007
Graduate Student of the Year, MPBC
2008
Contact
Research & Clinical Interests
Research Interests: 

Our team's research leverages cryo-electron microscopy (cryo-EM) and electrophysiology to study the voltage-gated sodium channel in the heart, Nav1.5, and its pharmacology. The primary focus is on the determination of the molecular basis of action for Class I anti-arrhythmic drugs (AAD), which are sodium channel blockers used to treat arrythmias in both the acute and chronic settings. To date, we have determined the structure of a prokaryotic sodium channel in complex with AAD and rat cardiac sodium channel in complex with flecainide and propafenone, allowing us to make comparison between the binding sites of these molecules and offer insight into their clinical uses. We are currently developing methods to study these drugs in complex with human Nav1.5 with the goal of using this information to inform current AAD use and future AAD development.  

Research Interests

  • Care of the hospitalized patient
  • Clinical reasoning
  • Teaching students and medical residents
  • Membrane proteins and ion channels
Publications
Publications: