John Amory, MD, MPH, MSc | Division of General Internal Medicine

Professor

Medicine

Section Head, University of Washington Medical Center

Faculty Information

Biography

Education & Training:

University of California, San Francisco

San Francisco, CA

1989–1994

Residency in Internal Medicine

University of California, San Francisco

San Francisco, CA

1994–1997

MPH

University of Washington

Seattle, WA

2004–2006

MSc

University of Washington

Seattle, WA

2017

Honors:

Dean's Prize for Medical Student Research

1992

Martin Memorial Award for Outstanding Second-Year Medicine Resident

1996

Weingarten Memorial Award for Outstanding Third-Year Medicine Resident

1997

Fellowship, American College of Physicians

2003

Alpha Omega Alpha, Honorary Inductee

2003

Paul Beeson Award for Excellence in Housestaff Instruction

2003

Helen and Phillip Fialkow Scholar

2004

Endocrine Society International Award for Excellence in Published Clinical Research

2005

Young Andrologist Award

2007

Elected Member, American Society of Clinical Investigation

2013

Contact

Email:

jamory@uw.edu

Research & Clinical Interests

Research Interests:

Male contraception
Androgens in aging
Testosterone deficiency
Klinefelter's Syndrome
Male infertility

Publications

Publications:

Amory JK, Wang C, Swerdloff R, Anawalt BD, Matsumoto AM, Bremner WJ, Walker SE, Haberer LJ, Clark RV. The Effect of 5α-Reductase Inhibition with Dutasteride and Finasteride on Semen Parameters and Serum Hormones in Healthy Men. Journal of Clinical Endocrinology and Metabolism 2007; 92:1659–1665.
Amory JK, Muller CH, Shimshoni AJ, Isoherranen N, Paik J, Moreb JS, Amory DW, Evanoff R, Goldstein AS, Griswold MD. Suppression of spermatogenesis by bisdichloroacetyldiamines is mediated by inhibition of testicular retinoic acid biosynthesis. Journal of Andrology 2011; 32(1):111–119. PMCID: PMC3370679.
Nya-Ngatchou JJ, Arnold SLM, Walsh TJ, Muller CH, Page ST, Isoherranen N, Amory JK. Intratesticular 13-cis Retinoic Acid is Reduced in Men with Abnormal Semen Analyses. Andrology 2013 March; 1: 325–331. PMCID: PMC3578657.
Amory JK, Arnold S, Walsh T, Lardone MC, Piottante A, Ebensperger MD, Isoherraenen N, Muller CH, Castro A. Levels of the Retinoic Acid Synthesizing Enzyme ALDH1A2 are Lower in Testicular Tissue from Men with Infertility. Fertility and Sterility 2014 Apr;101(4):960–966. PMCID:PMC3972330.
Paik J, Haenisch M, Muller CH, Goldstein AS, Arnold S, Isoherranen H, Brabb T, Treuting PM, Amory JK. Inhibition of Retinoic Acid Biosynthesis by WIN 18,446 Markedly Suppresses Spermatogenesis and alters Retinoid Metabolism in Mice. Journal of Biological Chemistry 2014 May 23;289(21):15104–17. PMCID: PMC4031560.
Amory JK, Ostrowski KA, Gannon JR, Berkseth K, Stevison F, Isoherranen N, Muller CH, Walsh T. Isotretinoin administration improves sperm production in some men with infertility from oligoasthenozoospermia: A Pilot Study. Andrology 2017 5:1115–1123.
Chen Y, Zhu J, Ho Hong K, Georg G, Goldstein AS, Amory JK, Schonbrunn E. Structural basis of ALDH1A2 inhibition by irreversible and reversible small molecule inhibitors. ACS Chemical Biology 2018 Mar 16;13(3):582–590.

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